Selective Targeting of Calcineurin Isoforms by Calcineurin Inhibitors
نویسندگان
چکیده
منابع مشابه
How calcineurin inhibitors cause hypertension.
Calcineurin is a calcium-dependent serine–threonine protein phosphatase. Calcineurin activates the nuclear factor of activated T-cells cytoplasmic (NFAT)c, a transcription factor, by dephosphorylating the protein. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T-...
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Cutaneous lupus erythematosus (CLE) encompasses a variety of lesions that may be refractory to systemic or topical agents. Discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE) are the most common lesions in clinical practice. The topical calcineurin inhibitors, tacrolimus and pimecrolimus, have been used to treat resistant cutaneous lupus since 2002 and inhibit th...
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(Suggestions are based on Level III and IV evidence) • In children treated with cyclosporin, 2 h peak cyclosporin level (C2) monitoring should be used in the initial post-transplant period, as the C2 level is a better predictor of cyclosporin exposure than C0 monitoring (Level III evidence). Limited data suggest that the C2 level should be maintained above 1500 ng/mL in the early post-transplan...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2021
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2021.35.s1.03685